Reaction Details |
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Target | Heat shock 70 kDa protein 1A |
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Ligand | BDBM82128 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence-Polarization (FP) Binding Assay |
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pH | 7.4±0 |
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Temperature | 298.15±0 K |
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Ki | 1.85e+3±n/a nM |
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Citation | Macias, AT; Williamson, DS; Allen, N; Borgognoni, J; Clay, A; Daniels, Z; Dokurno, P; Drysdale, MJ; Francis, GL; Graham, CJ; Howes, R; Matassova, N; Murray, JB; Parsons, R; Shaw, T; Surgenor, AE; Terry, L; Wang, Y; Wood, M; Massey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem54:4034-41 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Heat shock 70 kDa protein 1A |
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Name: | Heat shock 70 kDa protein 1A |
Synonyms: | HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70 |
Type: | Chaperone |
Mol. Mass.: | 70043.82 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 641 |
Sequence: | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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BDBM82128 |
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n/a |
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Name | BDBM82128 |
Synonyms: | 2-[(2R,3S,4R,5R)-5-(6-Amino-8-methylaminopurin-9-yl)- 3,4-dihydroxytetrahydrofuran-2-ylmethoxy]acetamide | adenosine-derived inhibitor (Grp78), 7 |
Type | Small organic molecule |
Emp. Form. | C13H19N7O5 |
Mol. Mass. | 353.3339 |
SMILES | CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COCC(N)=O)[C@@H](O)[C@H]1O |r| |
Structure |
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