Reaction Details |
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Target | Heat shock 70 kDa protein 1A |
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Ligand | BDBM32381 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SPR assay |
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pH | 7.4±0 |
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Temperature | 298.15±0 K |
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Kd | 5e+1±n/a nM |
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Citation | Macias, AT; Williamson, DS; Allen, N; Borgognoni, J; Clay, A; Daniels, Z; Dokurno, P; Drysdale, MJ; Francis, GL; Graham, CJ; Howes, R; Matassova, N; Murray, JB; Parsons, R; Shaw, T; Surgenor, AE; Terry, L; Wang, Y; Wood, M; Massey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem54:4034-41 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Heat shock 70 kDa protein 1A |
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Name: | Heat shock 70 kDa protein 1A |
Synonyms: | HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70 |
Type: | Chaperone |
Mol. Mass.: | 70043.82 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 641 |
Sequence: | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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BDBM32381 |
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n/a |
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Name | BDBM32381 |
Synonyms: | adenosine-derived inhibitor (Grp78), 14 | adenosine-derived inhibitor, 15 |
Type | Small organic molecule |
Emp. Form. | C28H26N8O4 |
Mol. Mass. | 538.5572 |
SMILES | Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc3ccc4ncccc4c3)nc12 |r| |
Structure |
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