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TargetHeat shock 70 kDa protein 1A
LigandBDBM32381
Substrate/Competitorn/a
Meas. Tech.SPR assay
pH7.4±0
Temperature298.15±0 K
Kd 5e+1±n/a nM
Citation Macias, ATWilliamson, DSAllen, NBorgognoni, JClay, ADaniels, ZDokurno, PDrysdale, MJFrancis, GLGraham, CJHowes, RMatassova, NMurray, JBParsons, RShaw, TSurgenor, AETerry, LWang, YWood, MMassey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem54:4034-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Heat shock 70 kDa protein 1A
Name:Heat shock 70 kDa protein 1A
Synonyms:HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70
Type:Chaperone
Mol. Mass.:70043.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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BDBM32381
n/a
NameBDBM32381
Synonyms:adenosine-derived inhibitor (Grp78), 14 | adenosine-derived inhibitor, 15
TypeSmall organic molecule
Emp. Form.C28H26N8O4
Mol. Mass.538.5572
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc3ccc4ncccc4c3)nc12 |r|
Structure
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