Reaction Details |
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Target | Ketol-acid reductoisomerase (NADP(+)) |
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Ligand | BDBM82144 |
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Substrate/Competitor | BDBM82142 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 8±0 |
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Temperature | 303.15±0 K |
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Ki | 3.116e+4± 9.26e+3 nM |
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Citation | Liu, XH; Chen, PQ; Wang, BL; Dong, WL; Li, YH; Xie, XQ; Li, ZM High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Chem Biol Drug Des75:228-32 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Ketol-acid reductoisomerase (NADP(+)) |
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Name: | Ketol-acid reductoisomerase (NADP(+)) |
Synonyms: | Acetohydroxy-acid isomeroreductase | Alpha-keto-beta-hydroxylacil reductoisomerase | ILVC_ECOLI | Ketol-acid reductoisomerase | ilvC |
Type: | Enzyme |
Mol. Mass.: | 54057.85 |
Organism: | Escherichia coli |
Description: | P05793 |
Residue: | 491 |
Sequence: | MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSG
LDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQP
LMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
NDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL
VEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLF
QKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVL
MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
NYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGY
MTDMKRIAVAG
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BDBM82144 |
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BDBM82142 |
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Name | BDBM82144 |
Synonyms: | Cyclopropane, 5 |
Type | Small organic molecule |
Emp. Form. | C5H7NO3 |
Mol. Mass. | 129.114 |
SMILES | NC(=O)C1(CC1)C(O)=O |
Structure |
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