| Reaction Details |
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 | Report a problem with these data |
| Target | Serum paraoxonase/arylesterase 1 |
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| Ligand | BDBM10868 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibtion Assay |
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| Ki | 2001000±0.0 nM |
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| IC50 | 1240000±0.0 nM |
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| Citation |  Ekinci, D; Sentürk, M; Beydemir, S; Küfrevioglu, OI; Supuran, CT An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides. Chem Biol Drug Des76:552-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serum paraoxonase/arylesterase 1 |
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| Name: | Serum paraoxonase/arylesterase 1 |
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| Synonyms: | A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 39719.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27169 |
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| Residue: | 355 |
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| Sequence: | MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
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| BDBM10868 |
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| n/a |
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| Name | BDBM10868 |
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| Synonyms: | 1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadiazole-2-sulfonamide 15 | 5-Amino-1,3,4-thiadiazole-2-sulphonamide (1) | 5-amino-1,3,4-thiadiazole-2-sulfonamide | CHEMBL265674 | aromatic/heteroaromatic sulfonamide 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C2H4N4O2S2 |
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| Mol. Mass. | 180.209 |
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| SMILES | Nc1nnc(s1)S(N)(=O)=O |
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| Structure | 
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