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TargetGamma-aminobutyric acid receptor subunit alpha-1
LigandBDBM50094670
Substrate/Competitorn/a
Ki 1000±n/a nM
CommentsPDSP_1142
Citation Foreman, MMFuller, RWRasmussen, KNelson, DLCalligaro, DOZhang, LBarrett, JEBooher, RNPaget, CJFlaugh, ME Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity. J Pharmacol Exp Ther270:1270-81 (1994) [PubMed]
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Gamma-aminobutyric acid receptor subunit alpha-1
Name:Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS
Type:Enzyme
Mol. Mass.:51770.21
Organism:Rattus norvegicus (Rat)
Description:P62813
Residue:455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGL
GERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKI
WTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACP
LKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMT
THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR
NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPL
IKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDR
LSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
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  Blast E-value cutoff:
BDBM50094670
n/a
NameBDBM50094670
Synonyms:1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indol-6-yl)-ethanone | CHEMBL276031 | LY 293284 | LY-293284 | LY-293384
TypeSmall organic molecule
Emp. Form.C19H26N2O
Mol. Mass.298.4225
SMILESCCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(C1)c23
Structure
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