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TargetOpioid receptors; mu & delta
LigandBDBM50027391
Substrate/Competitorn/a
Ki 169±n/a nM
CommentsPDSP_4105
Citation Codd EEShank RPSchupsky JJRaffa RB Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther 274:1263-70 (1995) [PubMed]
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Opioid receptors; mu & delta
Name:Opioid receptors; mu & delta
Synonyms:Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Voltage-gated potassium channel
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40465.04
Organism:Rattus norvegicus (rat)
Description:Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50027391
n/a
NameBDBM50027391
Synonyms:Acetic acid (1S,4S)-4-dimethylamino-1-ethyl-2,2-diphenyl-pentyl ester | Acetic acid 4-dimethylamino-1-ethyl-2,2-diphenyl-pentyl ester | Alphacetylmethadol | CHEMBL170179 | Methadyl acetate | alpha-(-)-Acetylmethadol
TypeSmall organic molecule
Emp. Form.C23H31NO2
Mol. Mass.353.4977
SMILESCCC(OC(C)=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1
Structure
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