Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM82507 |
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Substrate/Competitor | n/a |
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Ki | 371±n/a nM |
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Comments | PDSP_4113 |
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Citation | Codd, EE; Shank, RP; Schupsky, JJ; Raffa, RB Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther274:1263-70 (1995) [PubMed] |
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More Info.: | Get all data from this article |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40465.04 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
Residue: | 372 |
Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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BDBM82507 |
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n/a |
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Name | BDBM82507 |
Synonyms: | (+/-)-Methadone | CAS_5967-73-7 | METHADONE | Methadone-HCL,(-) | NSC_22266 |
Type | Small organic molecule |
Emp. Form. | C21H27NO |
Mol. Mass. | 309.4452 |
SMILES | CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 |
Structure |
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