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TargetTranscriptional regulator ERG
LigandBDBM251922
Substrate/Competitorn/a
Meas. Tech.hERG Inhibition Assay
IC50 12000±n/a nM
Citation Hoveyda, HRDutheuil, GFraser, GLRoy, MBousmaqui, MEBatt, F Chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof US Patent US10065961 Publication Date 9/4/2018
More Info.:Get all data from this article,  Assay Method
 
Transcriptional regulator ERG
Name:Transcriptional regulator ERG
Synonyms:ERG | ERG_HUMAN | Transforming protein ERG
Type:PROTEIN
Mol. Mass.:54615.84
Organism:Homo sapiens (Human)
Description:ChEMBL_1335569
Residue:486
Sequence:
MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM251922
n/a
NameBDBM251922
Synonyms:US10065961, Compound 22 | US10683295, Compound 22 | US10941151, Compound 22 | US9475814, 22
TypeSmall organic molecule
Emp. Form.C22H21N5OS2
Mol. Mass.435.565
SMILESC[C@H]1N(CCn2c1nnc2-c1nc(C)c(C)s1)C(=O)c1ccc(cc1)-c1cccs1 |r|
Structure
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