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Target5-hydroxytryptamine receptor 6
LigandBDBM22870
Substrate/Competitorn/a
Ki 6±n/a nM
CommentsPDSP_290
Citation Roth, BLCraigo, SCChoudhary, MSUluer, AMonsma, FJShen, YMeltzer, HYSibley, DR Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther268:1403-10 (1994) [PubMed]
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5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6
Type:Enzyme Catalytic Domain
Mol. Mass.:46945.51
Organism:RAT
Description:5-HT6 HTR6 RAT::P31388
Residue:436
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQC
RLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVP
RTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVP
DQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLS
QTLWSLRYGRIHSVPP
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  Blast E-value cutoff:
BDBM22870
n/a
NameBDBM22870
Synonyms:13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene | 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine | Amoxapine | Asendin | CHEMBL1113 | Demolox
TypeSmall organic molecule
Emp. Form.C17H16ClN3O
Mol. Mass.313.781
SMILESClc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1 |t:13|
Structure
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