| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM22567 |
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| Substrate/Competitor | n/a |
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| Ki | 1.25±n/a nM |
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| Comments | PDSP_1202 |
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| Citation |  Moguilevsky, N; Varsalona, F; Noyer, M; Gillard, M; Guillaume, JP; Garcia, L; Szpirer, C; Szpirer, J; Bollen, A Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Eur J Biochem224:489-95 (1994) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM22567 |
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| n/a |
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| Name | BDBM22567 |
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| Synonyms: | 3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramine | N-(4-methoxybenzyl)-N ,N -dimethyl-N-pyridin-2-ylethane-1,2-diamine | N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine | PYRILAMINE | Pyranisamine | [3H]mepyramine | [3H]pyrilamine |
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| Type | radiolabeled ligand |
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| Emp. Form. | C17H23N3O |
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| Mol. Mass. | 285.384 |
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| SMILES | COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 |
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| Structure | 
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