| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Ligand | BDBM273032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KAT-II inhibitory assay |
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| pH | 8±n/a |
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| IC50 | 13.0±n/a nM |
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| Comments | extracted |
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| Citation |  Okuyama, M; Fukunaga, K; Usui, K; Hayashi, N; Iijima, D; Horiuchi, H; Itagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 47353.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N5Z0 |
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| Residue: | 425 |
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| Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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| BDBM273032 |
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| n/a |
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| Name | BDBM273032 |
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| Synonyms: | 2-[(R)-1-(phenylacetyl)pyrrolidin-2-yl]-5-[1-(trifluoromethyl)cyclopropyl]-6H-[1,3]thiazolo[5,4-d]pyrimidin-7-one | US10065972, Example 97 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F3N4O2S |
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| Mol. Mass. | 448.461 |
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| SMILES | FC(F)(F)C1(CC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Cc1ccccc1 |r| |
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| Structure | 
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