Reaction Details |
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Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Ligand | BDBM273040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | KAT-II inhibitory assay |
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pH | 8±n/a |
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IC50 | 14.0±n/a nM |
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Comments | extracted |
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Citation | Okuyama, M; Fukunaga, K; Usui, K; Hayashi, N; Iijima, D; Horiuchi, H; Itagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
Type: | Enzyme |
Mol. Mass.: | 47353.09 |
Organism: | Homo sapiens (Human) |
Description: | Q8N5Z0 |
Residue: | 425 |
Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM273040 |
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n/a |
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Name | BDBM273040 |
Synonyms: | (R)-2-[5-(3-methyloxetan-3-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-1-carboxylic acid phenyl ester | US10065972, Example 116 |
Type | Small organic molecule |
Emp. Form. | C20H20N4O4S |
Mol. Mass. | 412.462 |
SMILES | CC1(COC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1 |r| |
Structure |
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