| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Ligand | BDBM273129 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KAT-II inhibitory assay |
|---|
| pH | 8±n/a |
|---|
| IC50 | 9.70±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Okuyama, M; Fukunaga, K; Usui, K; Hayashi, N; Iijima, D; Horiuchi, H; Itagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 47353.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8N5Z0 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
|
|
|
|---|
| BDBM273129 |
|---|
| n/a |
|---|
| Name | BDBM273129 |
|---|
| Synonyms: | (R)-N-benzyl-1-[5-(2-fluoropropan-2-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | US10065972, Example 482 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22FN5O2S |
|---|
| Mol. Mass. | 415.484 |
|---|
| SMILES | CC(C)(F)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
