| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM112777 |
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| Substrate/Competitor | n/a |
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| Ki | 84±n/a nM |
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| Comments | PDSP_1363 |
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| Citation |  Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochem Pharmacol45:2352-4 (1993) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM112777 |
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| n/a |
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| Name | BDBM112777 |
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| Synonyms: | NORTRIPTYLINE | US8629135, SW-02 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N |
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| Mol. Mass. | 263.3767 |
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| SMILES | [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 |
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| Structure | 
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