Ki Summary

Reaction Details

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Target

Endoribonuclease toxin MazF

Ligand

BDBM83585

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay

EC50

10700±n/a nM

Citation

PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Endoribonuclease toxin MazF

Name:

Endoribonuclease toxin MazF

Synonyms:

MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF

Type:

Enzyme Catalytic Domain

Mol. Mass.:

12100.43

Organism:

Escherichia coli str. K-12 substr. MG1655

Description:

gi_16130689

Residue:

111

Sequence:

MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPF
EVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG

BDBM83585

n/a

Name

BDBM83585

Synonyms:

(4Z)-4-[4-(dimethylamino)benzylidene]-1-(2-furfuryl)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester | (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(2-furanylmethyl)-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester | MLS000666160 | SMR000271460 | cid_1746835 | methyl (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(furan-2-ylmethyl)-2-methyl-5-oxidanylidene-pyrrole-3-carboxylate | methyl (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(furan-2-ylmethyl)-2-methyl-5-oxopyrrole-3-carboxylate | methyl 4-[4-(dimethylamino)benzylidene]-1-(2-furylmethyl)-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

Type

Small organic molecule

Emp. Form.

C21H22N2O4

Mol. Mass.

366.4104

SMILES

COC(=O)C1=C(C)N(Cc2ccco2)C(=O)\C1=C/c1ccc(cc1)N(C)C |c:4|

Structure