Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM44965

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59652±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM44965

n/a

Name

BDBM44965

Synonyms:

5-acetoxy-2-[(amidinothio)methyl]-6-bromo-1-(p-tolyl)indole-3-carboxylic acid ethyl ester;hydrobromide | 5-acetyloxy-6-bromo-2-[(carbamimidoylthio)methyl]-1-(4-methylphenyl)-3-indolecarboxylic acid ethyl ester;hydrobromide | MLS000545873 | SMR000163754 | cid_11948870 | ethyl 5-(acetyloxy)-2-({[amino(imino)methyl]sulfanyl}methyl)-6-bromo-1-(4-methylphenyl)-1H-indole-3-carboxylate | ethyl 5-acetyloxy-6-bromanyl-2-(carbamimidoylsulfanylmethyl)-1-(4-methylphenyl)indole-3-carboxylate;hydrobromide | ethyl 5-acetyloxy-6-bromo-2-(carbamimidoylsulfanylmethyl)-1-(4-methylphenyl)indole-3-carboxylate;hydrobromide

Type

Small organic molecule

Emp. Form.

C22H22BrN3O4S

Mol. Mass.

504.397

SMILES

CCOC(=O)c1c(CSC(N)=N)n(-c2ccc(C)cc2)c2cc(Br)c(OC(C)=O)cc12

Structure