Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM83826

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59718±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM83826

n/a

Name

BDBM83826

Synonyms:

(2S)-2-[[[(2R)-1-ethoxy-1-oxopropan-2-yl]-[(4-methoxyphenyl)methyl]sulfamoyl]-(phenylmethyl)amino]-3-methylbutanoic acid methyl ester | (2S)-2-[benzyl-[[(1R)-2-ethoxy-2-keto-1-methyl-ethyl]-p-anisyl-sulfamoyl]amino]-3-methyl-butyric acid methyl ester | MLS002240571 | SMR001308239 | cid_42628460 | methyl (2S)-2-[[[(2R)-1-ethoxy-1-oxidanylidene-propan-2-yl]-[(4-methoxyphenyl)methyl]sulfamoyl]-(phenylmethyl)amino]-3-methyl-butanoate | methyl (2S)-2-[benzyl-[[(2R)-1-ethoxy-1-oxopropan-2-yl]-[(4-methoxyphenyl)methyl]sulfamoyl]amino]-3-methylbutanoate

Type

Small organic molecule

Emp. Form.

C26H36N2O7S

Mol. Mass.

520.638

SMILES

CCOC(=O)[C@@H](C)N(Cc1ccc(OC)cc1)S(=O)(=O)N(Cc1ccccc1)[C@@H](C(C)C)C(=O)OC

Structure