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TargetApoptotic protease-activating factor 1
LigandBDBM47968
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay
IC50 1480±n/a nM
Citation PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay PubChem Bioassay(2011)[AID]
More Info.:Get all data from this article,  Assay Method
 
Apoptotic protease-activating factor 1
Name:Apoptotic protease-activating factor 1
Synonyms:APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413
Type:Enzyme Catalytic Domain
Mol. Mass.:141834.40
Organism:Homo sapiens (Human)
Description:O14727
Residue:1248
Sequence:
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM47968
n/a
NameBDBM47968
Synonyms:MLS000686315 | N-[4-({(4Z)-1-oxo-4-[(thien-2-ylsulfonyl)imino]-1,4-dihydronaphthalen-2-yl}amino)phenyl]acetamide | N-[4-[(1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl)amino]phenyl]ethanamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl)amino]phenyl]acetamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl)amino]phenyl]acetamide | N-[4-[[(4Z)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | N-[4-[[1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | SMR000313158 | cid_3715121
TypeSmall organic molecule
Emp. Form.C22H17N3O4S2
Mol. Mass.451.518
SMILESCC(=O)Nc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)cc1 |w:12.12,t:9|
Structure
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