| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptotic protease-activating factor 1 |
|---|
| Ligand | BDBM18 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay |
|---|
| IC50 | >100000±0 nM |
|---|
| Citation |  PubChem, PC Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptotic protease-activating factor 1 |
|---|
| Name: | Apoptotic protease-activating factor 1 |
|---|
| Synonyms: | APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 141834.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14727 |
|---|
| Residue: | 1248 |
|---|
| Sequence: | MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
|
|
|
|---|
| BDBM18 |
|---|
| n/a |
|---|
| Name | BDBM18 |
|---|
| Synonyms: | (3-amino-5-methyl-6-phenyl-phenanthridin-5-ium-8-yl)amine;bromide | 3,8-diamino-5-methyl-6-phenylphenanthridin-5-ium bromide | 5-methyl-6-phenyl-phenanthridin-5-ium-3,8-diamine;bromide | 5-methyl-6-phenylphenanthridin-5-ium-3,8-diamine;bromide | Dimidium bromide | MLS001074889 | SMR000568409 | cid_68207 | ethidium bromide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18N3 |
|---|
| Mol. Mass. | 300.3765 |
|---|
| SMILES | Cn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
