| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug resistance protein CDR1 |
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| Ligand | BDBM57893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr1 with Hit compounds from Cherry Pick1 |
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| EC50 | 27100±n/a nM |
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| Citation |  PubChem, PC Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr1 with Hit compounds from Cherry Pick1 PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug resistance protein CDR1 |
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| Name: | Multidrug resistance protein CDR1 |
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| Synonyms: | CDR1 | CDR1_CANAX | Multidrug resistance protein CDR1 | drug resistance protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 169942.67 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_708756 |
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| Residue: | 1501 |
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| Sequence: | MSDSKMSSQDESKLEKAISQDSSSENHSINEYHGFDAHTSENIQNLARTFTHDSFKDDSS
AGLLKYLTHMSEVPGVNPYEHEEINNDQLNPDSENFNAKFWVKNLRKLFESDPEYYKPSK
LGIGYRNLRAYGVANDSDYQPTVTNALWKLATEGFRHFQKDDDSRYFDILKSMDAIMRPG
ELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERHYRGDVIYSAETD
VHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATYGLSHTRNTNVGNDFV
RGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAI
YQCSQDAYDLFDKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAE
REPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSNTRETYRESHVAKQS
NNTRPASPYTVSFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTT
GSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADALASIISELPV
KLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMSHLFRSIGAVSTSISGAMTPA
TVLLLAMVIYTGFVIPTPSMLGWSRWINYINPVGYVFESLMVNEFHGREFQCAQYVPSGP
GYENISRSNQVCTAVGSVPGNEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYI
ALTEFNKGAMQKGEIVLFLKGSLKKHKRKTAASNKGDIEAGPVAGKLDYQDEAEAVNNEK
FTEKGSTGSVDFPENREIFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAG
KTTLLNCLSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLPTSTVREALQFSA
YLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQRKRLTIGVELVAKPK
LLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFLQKGGR
TAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSS
EYQAVREEINRMEAELSKLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSK
IFLVVSAALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDVYEVR
EAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNATPTDSVNPRGVLMWM
LVTAFYVYTATMGQLCMSFSELADNAANLATLLFTMCLNFCGVLAGPDVLPGFWIFMYRC
NPFTYLVQAMLSTGLANTFVKCAEREYVSVKPPNGESCSTYLDPYIKFAGGYFETRNDGS
CAFCQMSSTNTFLKSVNSLYSERWRNFGIFIAFIAINIILTVIFYWLARVPKGNREKKNK
K
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| BDBM57893 |
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| n/a |
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| Name | BDBM57893 |
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| Synonyms: | (2Z,5Z)-2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone | (2Z,5Z)-2,5-bis[(3-methoxy-4-oxidanyl-phenyl)methylidene]cyclopentan-1-one | (2Z,5Z)-2,5-bis[(4-hydroxy-3-methoxyphenyl)methylidene]-1-cyclopentanone | (2Z,5Z)-2,5-bis[(4-hydroxy-3-methoxyphenyl)methylidene]cyclopentan-1-one | (2Z,5Z)-2,5-divanillylidenecyclopentanone | MLS000681631 | SMR000312315 | cid_6477637 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20O5 |
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| Mol. Mass. | 352.3805 |
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| SMILES | COc1cc(\C=C2\CC\C(=C\c3ccc(O)c(OC)c3)C2=O)ccc1O |
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| Structure | 
|
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