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TargetToll-like receptor 7
LigandBDBM273340
Substrate/Competitorn/a
Meas. Tech.TLR7/8/9 Inhibition Reporter Assay
Temperature298.15±n/a K
IC50 0.200±n/a nM
Commentsextracted
Citation Dyckman AJDodd DSMacor JEMussari CPPasunoori LKumar SRSherwood TCSistla RK [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent  US10071079 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Toll-like receptor 7
Name:TLR7 and TLR8
Synonyms:ORF Names:UNQ248/PRO285 | TLR7 | Toll-like receptor 7 (TLR7)
Type:Enzyme
Mol. Mass.:120945.35
Organism:Homo sapiens (Human)
Description:Q9NYK1
Residue:1049
Sequence:
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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  Blast E-value cutoff:
BDBM273340
n/a
NameBDBM273340
Synonyms:US10071079, Example 119
TypeSmall organic molecule
Emp. Form.C23H26ClN5
Mol. Mass.407.939
SMILESCC(C)c1c([nH]c2ccc(cc12)C1CCNCC1)-c1cn2ncnc2c(Cl)c1C
Structure
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