| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 9 |
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| Ligand | BDBM273385 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TLR7/8/9 Inhibition Reporter Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 3414±n/a nM |
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| Comments | extracted |
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| Citation |  Dyckman, AJ; Dodd, DS; Macor, JE; Mussari, CP; Pasunoori, L; Kumar, SR; Sherwood, TC; Sistla, RK [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent US10071079 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 9 |
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| Name: | Toll-like receptor 9 |
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| Synonyms: | CD_antigen: CD289 | TLR9 | TLR9_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 115889.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR96 |
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| Residue: | 1032 |
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| Sequence: | MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE
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| BDBM273385 |
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| n/a |
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| Name | BDBM273385 |
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| Synonyms: | US10071079, Example 168 | US10478424, Example 168 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N6O2S |
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| Mol. Mass. | 480.626 |
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| SMILES | CC(C)c1c([nH]c2ccc(cc12)C1CCN(CCS(N)(=O)=O)CC1)-c1cc(C)c2ncnn2c1 |
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| Structure | 
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