Reaction Details | |||
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Report a problem with these data | |||
Target | Toll-like receptor 9 | ||
Ligand | BDBM273781 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 2235±n/a nM | ||
Comments | extracted | ||
Citation | Dyckman, AJ; Dodd, DS; Macor, JE; Mussari, CP; Pasunoori, L; Kumar, SR; Sherwood, TC; Sistla, RK [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent US10071079 Publication Date 9/11/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 9 | |||
Name: | Toll-like receptor 9 | ||
Synonyms: | CD_antigen: CD289 | TLR9 | TLR9_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 115889.91 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NR96 | ||
Residue: | 1032 | ||
Sequence: |
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BDBM273781 | |||
n/a | |||
Name | BDBM273781 | ||
Synonyms: | US10071079, Example 567 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32N6O | ||
Mol. Mass. | 468.5933 | ||
SMILES | COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC1)C1CC(C1)[N+]#[C-] |(10.48,.67,;8.94,.67,;8.17,-.67,;6.63,-.67,;5.86,-2,;6.63,-3.33,;8.17,-3.33,;9.2,-4.48,;10.61,-3.85,;10.45,-2.32,;8.94,-2,;4.32,-2,;3.41,-3.25,;1.95,-2.77,;.62,-3.54,;-.72,-2.77,;-.72,-1.23,;.62,-.46,;1.95,-1.23,;3.41,-.75,;3.81,.73,;2.72,1.82,;5.3,1.13,;-2.05,-.46,;-3.39,-1.23,;-4.72,-.46,;-4.72,1.08,;-3.39,1.85,;-2.05,1.08,;-6.05,1.85,;-6.45,3.34,;-7.96,2.95,;-7.54,1.45,;-9.29,3.72,;-10.63,4.49,)| | ||
Structure |