| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 8 |
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| Ligand | BDBM273990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TLR7/8/9 Inhibition Reporter Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 5.80±n/a nM |
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| Comments | extracted |
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| Citation |  Dyckman, AJ; Dodd, DS; Macor, JE; Mussari, CP; Pasunoori, L; Kumar, SR; Sherwood, TC; Sistla, RK [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent US10071079 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 8 |
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| Name: | Toll-like receptor 8 |
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| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119828.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR97 |
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| Residue: | 1041 |
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| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
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| BDBM273990 |
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| n/a |
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| Name | BDBM273990 |
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| Synonyms: | US10071079, Example 776 | US10478424, Example 776 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36N6O2 |
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| Mol. Mass. | 500.6351 |
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| SMILES | CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN1CC[C@@H](O)C1)-c1cc(C)c2ncnn2c1 |r| |
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| Structure | 
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