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TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A]
LigandBDBM84460
Substrate/Competitorn/a
Meas. Tech.Inhibiton Activity Assay
Ki 27±1 nM
IC50 46±2 nM
Citation Brik, AMuldoon, JLin, YCElder, JHGoodsell, DSOlson, AJFokin, VVSharpless, KBWong, CH Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem4:1246-8 (2003) [PubMed]  Article
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Gag-Pol polyprotein [489-587,G537V,H558K,V571A]
Name:Gag-Pol polyprotein [489-587,G537V,H558K,V571A]
Synonyms:HIV-1 protease | HIV-1 protease (G48V) | HIV-1 protease (V82A) | POL_HV1N5 | gag-pol
Type:Protein
Mol. Mass.:10827.77
Organism:Human immunodeficiency virus
Description:P12497[489-587,G537V,H558K,V571A]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
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BDBM84460
n/a
NameBDBM84460
Synonyms:HIV-1 PR Inhibitor, compound 6
TypeSmall organic molecule
Emp. Form.C34H41N5O7S
Mol. Mass.663.784
SMILESCOc1ccc(cc1)S(=O)(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc1ccccc1)n1cc(COC(=O)N[C@@H]2[C@H](O)Cc3ccccc23)nn1 |r|
Structure
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