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TargetThymidylate synthase
LigandBDBM50161779
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 1.8e+3±n/a nM
Citation Calò, STondi, DFerrari, SVenturelli, AGhelli, SCosti, MP Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases. Chembiochem9:779-90 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYSY_ECOLI | Thymidylate Synthase (TS) | thyA
Type:Enzyme
Mol. Mass.:30475.81
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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  Blast E-value cutoff:
BDBM50161779
n/a
NameBDBM50161779
Synonyms:(S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-[4-(5-dimethylamino-naphthalene-1-sulfonyloxy)-phenyl]-propionic acid | CHEMBL176072 | Dansyl derivative, DDT, 1L | Dansyl derivatives 18A, (R) isomer | Dansyltyrosine deriviative 21B | N,O-DIDANSYL-L-TYROSINE | N,O-diansyl-L-tyrosine
TypeSmall organic molecule
Emp. Form.C33H33N3O7S2
Mol. Mass.647.761
SMILESCN(C)c1cccc2c(cccc12)S(=O)(=O)N[C@@H](Cc1ccc(OS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1)C(O)=O
Structure
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