| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [44-477] |
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| Ligand | BDBM274336 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET In-Vitro Binding Assay |
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| pH | 7.5±n/a |
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| IC50 | <11.0±n/a nM |
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| Comments | extracted |
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| Citation |  Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [44-477] |
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| Name: | Bromodomain-containing protein 4 [44-477] |
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| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 | HUNK1 |
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| Type: | Enzyme Catalytic Domain (aa 44-477) |
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| Mol. Mass.: | 48692.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885[44-477] |
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| Residue: | 434 |
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| Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPH
PFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVK
TKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPA
PEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTI
KSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEE
PVVAVSSPAVPPPT
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| BDBM274336 |
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| n/a |
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| Name | BDBM274336 |
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| Synonyms: | (R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one | US9550796, Example 137 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24ClN5O2 |
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| Mol. Mass. | 473.954 |
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| SMILES | Cc1nnc2c(C)cc(cn12)N1[C@H](c2c(cc(C3=CCOCC3)n2C)C1=O)c1ccc(Cl)cc1 |r,t:19| |
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| Structure | 
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