| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM84651 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 277.15±0 K |
|---|
| IC50 | 52±n/a nM |
|---|
| Citation |  Sardon, T; Cottin, T; Xu, J; Giannis, A; Vernos, I Development and biological evaluation of a novel aurora A kinase inhibitor. Chembiochem10:464-78 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM84651 |
|---|
| n/a |
|---|
| Name | BDBM84651 |
|---|
| Synonyms: | TC-107 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14FN3O |
|---|
| Mol. Mass. | 295.311 |
|---|
| SMILES | OCC=Cc1ccc2ncnc(Nc3cccc(F)c3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
