| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 1 |
|---|
| Ligand | BDBM84649 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 277.15±0 K |
|---|
| IC50 | >1.00e+5±n/a nM |
|---|
| Citation |  Sardon, T; Cottin, T; Xu, J; Giannis, A; Vernos, I Development and biological evaluation of a novel aurora A kinase inhibitor. Chembiochem10:464-78 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 1 |
|---|
| Name: | Fibroblast growth factor receptor 1 |
|---|
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 91861.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11362 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
|
|
|
|---|
| BDBM84649 |
|---|
| n/a |
|---|
| Name | BDBM84649 |
|---|
| Synonyms: | TC-28 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H17N3O2 |
|---|
| Mol. Mass. | 307.3465 |
|---|
| SMILES | CC(C)Nc1nc(nc2ccc(cc12)C#CCO)-c1ccco1 |
|---|
| Structure | 
|
|---|
Search and Browse
