| Reaction Details |
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 | Report a problem with these data |
| Target | Choline/ethanolamine kinase |
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| Ligand | BDBM50239117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1665291 (CHEMBL4015087) |
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| IC50 | >50000±n/a nM |
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| Citation |  Barlaam, B; Cosulich, S; Degorce, S; Ellston, R; Fitzek, M; Green, S; Hancox, U; Lambert-van der Brempt, C; Lohmann, JJ; Maudet, M; Morgentin, R; Plé, P; Ward, L; Warin, N Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3K?/? inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett27:1949-1954 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Choline/ethanolamine kinase |
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| Name: | Choline/ethanolamine kinase |
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| Synonyms: | CHETK | CHKB | CHKB_HUMAN | CHKL | CK | CKB | CKEKB | Choline kinase beta | Choline kinase-like protein | EK | EKB | Ethanolamine kinase | Ethanolamine kinase beta | choline/ethanolamine kinase beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45262.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108033 |
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| Residue: | 395 |
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| Sequence: | MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS
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| BDBM50239117 |
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| n/a |
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| Name | BDBM50239117 |
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| Synonyms: | CHEMBL4060768 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29F2N3O5 |
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| Mol. Mass. | 525.5438 |
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| SMILES | Fc1cc(F)cc(c1)N1CCC[C@@H]1c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCOCC1 |r| |
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| Structure | 
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