Ki Summary

Reaction Details

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Target

Ribonucleoside-diphosphate reductase large subunit

Ligand

BDBM50000137

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_195384

IC50

4600±n/a nM

Citation

Gaudreau, P; Brazeau, P; Richer, M; Cormier, J; Langlois, D; Langelier, Y Structure-function studies of peptides inhibiting the ribonucleotide reductase activity of herpes simplex virus type I. J Med Chem35:346-50 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Ribonucleoside-diphosphate reductase large subunit

Name:

Ribonucleoside-diphosphate reductase large subunit

Synonyms:

Type:

PROTEIN

Mol. Mass.:

90074.67

Organism:

Homo sapiens (Human)

Description:

ChEMBL_90946

Residue:

792

Sequence:

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS

BDBM50000137

n/a

Name

BDBM50000137

Synonyms:

CHEMBL263845 | Ribonucleotide reductase inhibiting peptide analogue

Type

Small organic molecule

Emp. Form.

C48H76N10O16

Mol. Mass.

1049.1744

SMILES

CC[C@@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

Structure