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TargetCytochrome P450 2C8
LigandBDBM50239252
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1665796 (CHEMBL4015592)
IC50 1000±n/a nM
Citation Yeung, KSBeno, BRParcella, KBender, JAGrant-Young, KANickel, AGunaga, PAnjanappa, PBora, ROSelvakumar, KRigat, KWang, YKLiu, MLemm, JMosure, KSheriff, SWan, CWitmer, MKish, KHanumegowda, UZhuo, XShu, YZParker, DHaskell, RNg, AGao, QColston, ERaybon, JGrasela, DMSantone, KGao, MMeanwell, NASinz, MSoars, MGKnipe, JORoberts, SBKadow, JF Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem60:4369-4385 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2C8
Name:Cytochrome P450 2C8
Synonyms:CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:Protein
Mol. Mass.:55839.23
Organism:Homo sapiens (Human)
Description:P10632
Residue:490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50239252
n/a
NameBDBM50239252
Synonyms:CHEMBL4078188
TypeSmall organic molecule
Emp. Form.C32H26FN3O3
Mol. Mass.519.5655
SMILESCNC(=O)c1c(oc2ccc(cc12)-c1cc(ccc1C)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1
Structure
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