| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50000263 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_145682 |
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| IC50 | 160±n/a nM |
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| Citation |  Scopes, DI; Hayes, NF; Bays, DE; Belton, D; Brain, J; Brown, DS; Judd, DB; McElroy, AB; Meerholz, CA; Naylor, A New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus. J Med Chem35:490-501 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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|
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| BDBM50000263 |
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| n/a |
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| Name | BDBM50000263 |
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| Synonyms: | 2-(3,4-Dichloro-phenyl)-1-(8-pyrrolidin-1-ylmethyl-1,4-dioxa-7-aza-spiro[4.5]dec-7-yl)-ethanone | CHEMBL358727 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26Cl2N2O3 |
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| Mol. Mass. | 413.338 |
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| SMILES | Clc1ccc(CC(=O)N2CC3(CC[C@H]2CN2CCCC2)OCCO3)cc1Cl |
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| Structure | 
|
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