| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrases; II & IX |
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| Ligand | BDBM50239283 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1665868 |
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| Ki | 3.3±n/a nM |
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| Citation |  Bruno E; Buemi MR; Di Fiore A; De Luca L; Ferro S; Angeli A; Cirilli R; Sadutto D; Alterio V; Monti SM; Supuran CT; De Simone G; Gitto R Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides. J Med Chem 60:4316-4326 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrases; II & IX |
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| Name: | Carbonic anhydrases; II & IX |
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| Synonyms: | CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50239283 |
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| n/a |
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| Name | BDBM50239283 |
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| Synonyms: | CHEMBL4068642 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N2O5S |
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| Mol. Mass. | 424.47 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)C(=O)N1CCc2cc(O)c(O)cc2[C@H]1c1ccccc1 |r| |
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| Structure | 
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