Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50239273 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1665871 (CHEMBL4015667) |
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Ki | 847±n/a nM |
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Citation | Bruno, E; Buemi, MR; Di Fiore, A; De Luca, L; Ferro, S; Angeli, A; Cirilli, R; Sadutto, D; Alterio, V; Monti, SM; Supuran, CT; De Simone, G; Gitto, R Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides. J Med Chem60:4316-4326 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50239273 |
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n/a |
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Name | BDBM50239273 |
Synonyms: | CHEMBL4062013 |
Type | Small organic molecule |
Emp. Form. | C24H23BrN2O5S |
Mol. Mass. | 531.419 |
SMILES | COc1cc2CCN(C(c3ccc(Br)cc3)c2cc1OC)C(=O)c1ccc(cc1)S(N)(=O)=O |
Structure |
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