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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM50239499
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1666191
IC50 2.0±n/a nM
Citation Lee KLAmbler CMAnderson DRBoscoe BPBree AGBrodfuehrer JIChang JSChoi CChung SCurran KJDay JEDehnhardt CMDower KDrozda SEFrisbie RKGavrin LKGoldberg JAHan SHegen MHepworth DHope HRKamtekar SKilty ICLee ALin LLLovering FELowe MDMathias JPMorgan HMMurphy EAPapaioannou NPatny APierce BSRao VRSaiah ESamardjiev IJSamas BMShen MWHShin JHSoutter HHStrohbach JWSymanowicz PTThomason JRTrzupek JDVargas RVincent FYan JZapf CWWright SW Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem 60:5521-5542 (2017) [PubMed]  Article
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Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50239499
n/a
NameBDBM50239499
Synonyms:CHEMBL4081711
TypeSmall organic molecule
Emp. Form.C18H20FN3O4
Mol. Mass.361.3675
SMILESCC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F |r|
Structure
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