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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM50239506
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1666148 (CHEMBL4015944)
IC50 1.9±n/a nM
Citation Lee, KLAmbler, CMAnderson, DRBoscoe, BPBree, AGBrodfuehrer, JIChang, JSChoi, CChung, SCurran, KJDay, JEDehnhardt, CMDower, KDrozda, SEFrisbie, RKGavrin, LKGoldberg, JAHan, SHegen, MHepworth, DHope, HRKamtekar, SKilty, ICLee, ALin, LLLovering, FELowe, MDMathias, JPMorgan, HMMurphy, EAPapaioannou, NPatny, APierce, BSRao, VRSaiah, ESamardjiev, IJSamas, BMShen, MWHShin, JHSoutter, HHStrohbach, JWSymanowicz, PTThomason, JRTrzupek, JDVargas, RVincent, FYan, JZapf, CWWright, SW Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem60:5521-5542 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50239506
n/a
NameBDBM50239506
Synonyms:CHEMBL4071526 | US10329302, Example 188 | US10793579, Example 188 | US11702424, Example 188
TypeSmall organic molecule
Emp. Form.C17H18FN3O4
Mol. Mass.347.3409
SMILESCOc1cc2c(OC[C@H]3NC(=O)[C@H](F)[C@H]3C)nccc2cc1C(N)=O |r|
Structure
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