| Reaction Details |
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 | Report a problem with these data |
| Target | dCTP pyrophosphatase 1 |
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| Ligand | BDBM50239518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1666223 (CHEMBL4016019) |
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| IC50 | 36±n/a nM |
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| Citation |  Llona-Minguez, S; Höglund, A; Ghassemian, A; Desroses, M; Calderón-Montaño, JM; Burgos Morón, E; Valerie, NCK; Wiita, E; Almlöf, I; Koolmeister, T; Mateus, A; Cazares-Körner, C; Sanjiv, K; Homan, E; Loseva, O; Baranczewski, P; Darabi, M; Mehdizadeh, A; Fayezi, S; Jemth, AS; Warpman Berglund, U; Sigmundsson, K; Lundbäck, T; Jenmalm Jensen, A; Artursson, P; Scobie, M; Helleday, T Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. J Med Chem60:4279-4292 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| dCTP pyrophosphatase 1 |
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| Name: | dCTP pyrophosphatase 1 |
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| Synonyms: | DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1) |
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| Type: | Protein |
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| Mol. Mass.: | 18673.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H773 |
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| Residue: | 170 |
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| Sequence: | MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
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| BDBM50239518 |
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| n/a |
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| Name | BDBM50239518 |
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| Synonyms: | CHEMBL4075978 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN6O3S |
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| Mol. Mass. | 470.52 |
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| SMILES | Cc1ncccc1S(=O)(=O)N1CCN(CC1)c1ccc(nn1)C(=O)NCc1ccc(F)cc1 |
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| Structure | 
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