| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Ligand | BDBM50000673 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_76253 |
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| IC50 | 220±n/a nM |
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| Citation |  Leach, CA; Brown, TH; Ife, RJ; Keeling, DJ; Laing, SM; Parsons, ME; Price, CA; Wiggall, KJ Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent. J Med Chem35:1845-52 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
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| Synonyms: | Potassium-transporting ATPase alpha chain 1/beta chain |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 76252 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Potassium-transporting ATPase subunit beta |
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| Synonyms: | ATP4B_RAT | Atp4b | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase subunit beta | Proton pump beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33694.62 |
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| Organism: | Rattus norvegicus |
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| Description: | EBI_10720 |
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| Residue: | 294 |
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| Sequence: | MAALQEKKSCSQRMAEFRQYCWNPDTGQMLGRTPARWVWISLYYAAFYVVMTGLFALCIY
VLMQTIDPYTPDYQDQLKSPGVTLRPDVYGERGLQISYNISENSSWAGLTHTLHSFLAGY
TPASQQDSINCSSEKYFFQETFSAPNHTKFSCKFTADMLQNCSGLVDPSFGFEEGKPCFI
IKMNRIVKFLPSNNTAPRVDCTFQDDPQKPRKDIEPLQVQYYPPNGTFSLHYFPYYGKKA
QPHYSNPLVAAKFLNVPKNTQVLIVCKIMADHVTFDNPHDPYEGKVEFKLTIQK
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| Component 2 |
| Name: | Potassium-transporting ATPase alpha chain 1 |
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| Synonyms: | ATP4A_RAT | Atp4a | Hka | Potassium-transporting ATPase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114028.02 |
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| Organism: | Rattus norvegicus |
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| Description: | EBI_12422 |
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| Residue: | 1033 |
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| Sequence: | MGKENYELYSVELGTGPGGDMAAKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVSEL
EQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAIC
LIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATV
IRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPEC
THESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHF
VDIIAGLAILFGATFFVVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRL
ASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTF
DQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYR
DRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLD
EQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYTFDVEAMNFPSSGLCFAGLVSM
IDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMP
VDQVNKKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAI
VAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDN
LKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDI
MHLRPRNPRRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWE
DHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFR
NRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVR
CCPGSWWDQELYY
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| BDBM50000673 |
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| n/a |
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| Name | BDBM50000673 |
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| Synonyms: | 6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-4-ylamine | CHEMBL300848 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3 |
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| Mol. Mass. | 289.3743 |
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| SMILES | Cc1ccccc1N1CCc2c1c1cccc(C)c1nc2N |
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| Structure | 
|
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