| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
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| Ligand | BDBM50239717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1666753 (CHEMBL4016549) |
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| IC50 | >20000±n/a nM |
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| Citation |  Liu, Q; Shi, Q; Marcoux, D; Batt, DG; Cornelius, L; Qin, LY; Ruan, Z; Neels, J; Beaudoin-Bertrand, M; Srivastava, AS; Li, L; Cherney, RJ; Gong, H; Watterson, SH; Weigelt, C; Gillooly, KM; McIntyre, KW; Xie, JH; Obermeier, MT; Fura, A; Sleczka, B; Stefanski, K; Fancher, RM; Padmanabhan, S; Rp, T; Kundu, I; Rajareddy, K; Smith, R; Hennan, JK; Xing, D; Fan, J; Levesque, PC; Ruan, Q; Pitt, S; Zhang, R; Pedicord, D; Pan, J; Yarde, M; Lu, H; Lippy, J; Goldstine, C; Skala, S; Rampulla, RA; Mathur, A; Gupta, A; Arunachalam, PN; Sack, JS; Muckelbauer, JK; Cvijic, ME; Salter-Cid, LM; Bhide, RS; Poss, MA; Hynes, J; Carter, PH; Macor, JE; Ruepp, S; Schieven, GL; Tino, JA Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase? (PI3K?) Inhibitor for the Treatment of Immunological Disorders. J Med Chem60:5193-5208 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C8 |
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| Name: | Cytochrome P450 2C8 |
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| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 55839.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10632 |
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| Residue: | 490 |
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| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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| BDBM50239717 |
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| n/a |
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| Name | BDBM50239717 |
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| Synonyms: | CHEMBL4059848 | US10214537, Example 657 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25F3N8O2 |
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| Mol. Mass. | 526.5136 |
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| SMILES | CC(=O)N1CCN(C(=O)C1(C)C)c1cccc(c1)-c1cc(-c2ccnn2CC(F)(F)F)c2c(N)ncnn12 |
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| Structure | 
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