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TargetDNA polymerase beta
LigandBDBM50020676
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1667556
IC50 19000±n/a nM
Citation Zhou SMahmoud SLiu PZhou LEhteshami MBassit LTao SDomaoal RASari OSchutter CAmiralaei SKhalil AOllinger Russell OMcBrayer TWhitaker TAbou-Taleb NAmblard FCoats SJSchinazi RF 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture. J Med Chem 60:5424-5437 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase beta
Name:DNA polymerase beta
Synonyms:DNA polymerase beta (Pol β)
Type:Protein
Mol. Mass.:38188.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50020676
n/a
NameBDBM50020676
Synonyms:CHEBI:41846 | CHEMBL566812
TypeSmall organic molecule
Emp. Form.C10H17N2O13P3
Mol. Mass.466.1689
SMILESCc1cn([C@H]2CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r|
Structure
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