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TargetCytochrome P450 2D6
LigandBDBM50240277
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1667939 (CHEMBL4017827)
IC50 32000±n/a nM
Citation Roecker, AJEgbertson, MJones, KLGGomez, RKraus, RLLi, YKoser, AJUrban, MOKlein, RClements, MPanigel, JDaley, CWang, JFinger, ENMajercak, JSantarelli, VGregan, ICato, MFilzen, TJovanovska, AWang, YHWang, DJoyce, LASherer, ECPeng, XWang, XSun, HColeman, PJHoughton, AKLayton, ME Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na Bioorg Med Chem Lett27:2087-2093 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50240277
n/a
NameBDBM50240277
Synonyms:CHEMBL4061793
TypeSmall organic molecule
Emp. Form.C17H20ClFN4O2S2
Mol. Mass.430.948
SMILESFc1cc(NCC23CCCN2CCC3)c(Cl)cc1S(=O)(=O)Nc1nccs1
Structure
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