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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein kinase C theta type | ||
| Ligand | BDBM50240305 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1668070 (CHEMBL4017958) | ||
| IC50 | 0.086000±n/a nM | ||
| Citation |  Katoh, T; Tomata, Y; Setoh, M; Sasaki, S; Takai, T; Yoshitomi, Y; Yukawa, T; Nakagawa, H; Fukumoto, S; Tsukamoto, T; Nakada, Y Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors. Bioorg Med Chem Lett27:2497-2501 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein kinase C theta type | |||
| Name: | Protein kinase C theta type | ||
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 81878.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
| Residue: | 706 | ||
| Sequence: |
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| BDBM50240305 | |||
| n/a | |||
| Name | BDBM50240305 | ||
| Synonyms: | CHEMBL4082370 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21ClN6O2 | ||
| Mol. Mass. | 388.851 | ||
| SMILES | CCOc1ccnc2[nH]c(=O)n(-c3nc(ccc3Cl)N3CCCNCC3)c12 |(9.86,-25.53,;10.33,-24.06,;9.3,-22.92,;7.8,-23.24,;7.33,-24.7,;5.81,-25.02,;4.79,-23.88,;5.27,-22.42,;4.5,-21.09,;5.53,-19.94,;5.21,-18.44,;6.93,-20.57,;8.27,-19.8,;9.61,-20.57,;10.94,-19.8,;10.94,-18.25,;9.6,-17.48,;8.27,-18.26,;6.94,-17.49,;12.28,-20.56,;13.54,-19.7,;15.02,-20.15,;15.59,-21.57,;14.82,-22.91,;13.3,-23.15,;12.17,-22.1,;6.77,-22.1,)| | ||
| Structure | 
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