Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50240543 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1668372 (CHEMBL4018260) |
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IC50 | 478±n/a nM |
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Citation | Bender, AM; Weiner, RL; Luscombe, VB; Cho, HP; Niswender, CM; Engers, DW; Bridges, TM; Conn, PJ; Lindsley, CW Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. Bioorg Med Chem Lett27:2479-2483 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52841.70 |
Organism: | RAT |
Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
Residue: | 477 |
Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50240543 |
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n/a |
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Name | BDBM50240543 |
Synonyms: | CHEMBL4096589 |
Type | Small organic molecule |
Emp. Form. | C24H22F2N4O2 |
Mol. Mass. | 436.4539 |
SMILES | Fc1ccc(Oc2cc(ncn2)N2CCC(CC2)C(=O)N2Cc3ccccc3C2)c(F)c1 |
Structure |
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