| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
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| Ligand | BDBM50240780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1668764 (CHEMBL4018652) |
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| IC50 | >1000±n/a nM |
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| Citation |  Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer. J Med Chem60:6018-6035 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor TYRO3 |
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| Name: | Tyrosine-protein kinase receptor TYRO3 |
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| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
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| Type: | Protein |
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| Mol. Mass.: | 96894.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06418 |
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| Residue: | 890 |
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| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
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| BDBM50240780 |
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| n/a |
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| Name | BDBM50240780 |
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| Synonyms: | CHEMBL4062877 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23FN4O2 |
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| Mol. Mass. | 454.4955 |
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| SMILES | Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1cc(F)ccc1O |r| |
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| Structure | 
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