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TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
LigandBDBM3096
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1668981 (CHEMBL4018869)
Kd 247±n/a nM
Citation Zhu, JYCuellar, RABerndt, NLee, HEOlesen, SHMartin, MPJensen, JTGeorg, GISchönbrunn, E Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem60:7863-7875 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Name:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:PROTEIN
Mol. Mass.:54523.76
Organism:Homo sapiens (Human)
Description:ChEMBL_587209
Residue:499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT
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  Blast E-value cutoff:
BDBM3096
n/a
NameBDBM3096
Synonyms:2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, Dihydrochloride | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL49120 | D3RKN_84 | PD166285
TypeSmall organic molecule
Emp. Form.C26H27Cl2N5O2
Mol. Mass.512.431
SMILESCCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)|
Structure
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