| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase 2 |
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| Ligand | BDBM31545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1668980 (CHEMBL4018868) |
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| Kd | 27±n/a nM |
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| Citation |  Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem60:7863-7875 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase 2 |
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| Name: | Wee1-like protein kinase 2 |
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| Synonyms: | WEE1B | WEE2 | WEE2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62923.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774226 |
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| Residue: | 567 |
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| Sequence: | MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKGEVQDSEAKGTPPWTPL
SNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRSKLLPSDSPSTPKTMLSRL
VISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDL
EEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAI
KRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAA
ISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIE
EVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFAL
GLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL
ARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTG
SRSTKRLVGGKSARSSSFTSGEREPLH
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| BDBM31545 |
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| n/a |
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| Name | BDBM31545 |
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| Synonyms: | Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxamide, 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N8O |
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| Mol. Mass. | 460.5746 |
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| SMILES | CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21 |
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| Structure | 
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