Reaction Details |
| Report a problem with these data |
Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
---|
Ligand | BDBM50240975 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1669406 (CHEMBL4019294) |
---|
IC50 | 8486±n/a nM |
---|
Citation | Beaufils, F; Cmiljanovic, N; Cmiljanovic, V; Bohnacker, T; Melone, A; Marone, R; Jackson, E; Zhang, X; Sele, A; Borsari, C; Mestan, J; Hebeisen, P; Hillmann, P; Giese, B; Zvelebil, M; Fabbro, D; Williams, RL; Rageot, D; Wymann, MP 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J Med Chem60:7524-7538 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phosphatidylinositol 3-kinase catalytic subunit type 3 |
---|
Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
Type: | Enzyme |
Mol. Mass.: | 101551.30 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
Residue: | 887 |
Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
|
|
|
BDBM50240975 |
---|
n/a |
---|
Name | BDBM50240975 |
Synonyms: | CHEMBL4084907 |
Type | Small organic molecule |
Emp. Form. | C17H20F3N7O2 |
Mol. Mass. | 411.3816 |
SMILES | Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F |
Structure |
|