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TargetMitogen-activated protein kinase 14
LigandBDBM50241026
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1669514 (CHEMBL4019402)
IC50 1.6±n/a nM
Citation Walter, NMWentsch, HKBührmann, MBauer, SMDöring, EMayer-Wrangowski, SSievers-Engler, AWillemsen-Seegers, NZaman, GBuijsman, RLämmerhofer, MRauh, DLaufer, SA Design, Synthesis, and Biological Evaluation of Novel Type I J Med Chem60:8027-8054 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50241026
n/a
NameBDBM50241026
Synonyms:CHEMBL4069033
TypeSmall organic molecule
Emp. Form.C32H29FN4O5S
Mol. Mass.600.66
SMILESFc1ccc(Nc2ccc3c(OCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1cccs1
Structure
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