| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50241010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1669516 (CHEMBL4019404) |
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| IC50 | 0.280000±n/a nM |
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| Citation |  Walter, NM; Wentsch, HK; Bührmann, M; Bauer, SM; Döring, E; Mayer-Wrangowski, S; Sievers-Engler, A; Willemsen-Seegers, N; Zaman, G; Buijsman, R; Lämmerhofer, M; Rauh, D; Laufer, SA Design, Synthesis, and Biological Evaluation of Novel Type I J Med Chem60:8027-8054 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50241010 |
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| n/a |
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| Name | BDBM50241010 |
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| Synonyms: | CHEMBL4074237 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H30FN3O5 |
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| Mol. Mass. | 567.6068 |
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| SMILES | Cc1cc(F)c(NC(=O)c2ccccc2)cc1Nc1ccc2c(CCc3ccc(cc3C2=O)C(=O)NC[C@@H](O)CO)c1 |r| |
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| Structure | 
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